Aloesin is a C-glycosylated chromone derivative primarily isolated from Aloe vera and related Aloe species. It functions as a potent tyrosinase inhibitor, contributing to its widespread use in cosmetic formulations for skin lightening and hyperpigmentation treatment. The compound exhibits antioxidant, anti-inflammatory, and UV-protective properties. Structurally, it features a 5-methylchromone core substituted with a 2-oxopropyl group and a glucose unit attached through a stable C-glycosidic bond at position 8. Research indicates aloesin does not cause the cytotoxicity or ochronosis associated with hydroquinone. It is stable under typical formulation conditions and shows good bioavailability in topical applications.