Hesperidin is a flavanone glycoside abundant in citrus fruits including oranges, lemons, and grapefruits. It comprises the aglycone hesperetin linked to the disaccharide rutinose via a glycosidic bond at the 7-position. This compound demonstrates significant antioxidant, anti-inflammatory, and capillary-stabilizing activities. It is widely utilized in dietary supplements for vascular health, venous insufficiency relief, and oxidative stress reduction. Hesperidin modulates signaling pathways involved in inflammation and metabolism, with emerging research on its roles in cardiovascular protection and metabolic syndrome management. It occurs naturally as a white to pale yellow crystalline powder.