Pleurotin is a naturally occurring sesquiterpenoid quinone antibiotic metabolite produced by the basidiomycete fungus Pleurotus griseus. First isolated in the mid-20th century, it displays notable antibacterial and antifungal activity through interference with microbial metabolic pathways. The molecule possesses a complex polycyclic structure incorporating a quinone core fused with additional rings derived from farnesyl pyrophosphate precursors. Although studied for potential therapeutic applications, pleurotin has not advanced to clinical use owing to its toxicity profile and limited spectrum. Research continues on its biosynthesis and structural analogs for improved bioactivity. Physical properties include a melting point near 202 °C and poor aqueous solubility consistent with its lipophilic character.